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Das T, Paino D, Manoharan A, et al

Stopping retatrutide while continuing tesamorelin removes the appetite suppression and metabolic rate enhancement, potentially leading to weight regain while visceral fat reduction continues

195,196,197 At the cellular level, this translates into a massive increase in cytoplasmic Na + concentration, membrane depolarisation and opening of voltage-gated Ca 2+ channels, which in turn promotes massive release of glutamate that results in even large depolarisation enlarging Na + and Ca 2+ influx thus completing the vicious circle of excitotoxic damage, as Ca 2+ overload triggers necrotic cell death

doi: 10.1097/mjt.0000000000001196 37 LeeC